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Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α.

作者信息

Yang Zhou, Quan Yingjun, Chen Yusheng, Huang Yijun, Huang Renhong, Yu Weiping, Wu Dejun, Ye Min, Min Zhijun, Yu Bo

机构信息

Department of General Surgery, Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.

Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Signal Transduct Target Ther. 2021 Feb 27;6(1):89. doi: 10.1038/s41392-021-00473-y.

DOI:10.1038/s41392-021-00473-y
PMID:33637677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910535/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ce/7910535/698cb89e3a22/41392_2021_473_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ce/7910535/698cb89e3a22/41392_2021_473_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ce/7910535/698cb89e3a22/41392_2021_473_Fig1_HTML.jpg

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本文引用的文献

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Anti-tumour immunity controlled through mRNA mA methylation and YTHDF1 in dendritic cells.通过树突状细胞中的 mRNA mA 甲基化和 YTHDF1 控制抗肿瘤免疫。
Nature. 2019 Feb;566(7743):270-274. doi: 10.1038/s41586-019-0916-x. Epub 2019 Feb 6.
3
RNA mA methylation regulates the ultraviolet-induced DNA damage response.
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Mol Med. 2025 Mar 18;31(1):105. doi: 10.1186/s10020-025-01149-x.
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Interaction of the intestinal cytokines-JAKs-STAT3 and 5 axes with RNA N6-methyladenosine to promote chronic inflammation-induced colorectal cancer.肠道细胞因子-JAKs-STAT3和5轴与RNA N6-甲基腺苷相互作用以促进慢性炎症诱导的结直肠癌
Front Oncol. 2024 Jul 29;14:1352845. doi: 10.3389/fonc.2024.1352845. eCollection 2024.
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B7-H3 enhances colorectal cancer progression by regulating HB-EGF via HIF-1α.B7-H3通过HIF-1α调节HB-EGF来促进结直肠癌进展。
J Gastrointest Oncol. 2024 Jun 30;15(3):1035-1049. doi: 10.21037/jgo-24-384. Epub 2024 Jun 27.
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Abnormal changes in metabolites caused by mA methylation modification: The leading factors that induce the formation of immunosuppressive tumor microenvironment and their promising potential for clinical application.由mA甲基化修饰引起的代谢物异常变化：诱导免疫抑制肿瘤微环境形成的主要因素及其临床应用的潜在前景。
J Adv Res. 2025 Apr;70:159-186. doi: 10.1016/j.jare.2024.04.016. Epub 2024 Apr 25.
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