Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
McMaster University, Hamilton, ON, Canada.
Ann Surg Oncol. 2021 Sep;28(9):5183-5193. doi: 10.1245/s10434-021-09619-2. Epub 2021 Feb 26.
To assess the impact of animation deformity on health-related quality of life, a content-specific, valid, and reliable patient-reported outcome measure is needed. This report describes the development and validation of the BREAST-Q Animation Deformity scale.
Women with breast cancer who had an implant-based reconstruction provided data. In phase 1 (January 2017 and December 2018), qualitive and cognitive patient interviews and expert input were used to develop and refine scale content. In phase 2 (March to June 2019), a field test study with members of the Love Research Army (LRA) was conducted. Rasch Measurement Theory (RMT) analysis was used to examine psychometric properties.
In phase 1 of the study, qualitative (n = 11) and cognitive (n = 4) interview data and expert input (n = 9) led to the development of a 12-item scale measuring animation deformity. In phase 2, 651 LRA members provided data and 349 participated in a test-retest study. In the RMT analysis, the data fit the Rasch model (X(96) = 104.06; p = 0.27). The scale's reliability was high, with person separation index and Cronbach alpha values with/without extremes of ≥ 0.84 and ≥ 0.92 respectively, and an intraclass correlation coefficient of 0.92 (95% confidence interval, 0.90-0.94). Mean scores on the Animation Deformity scale varied as predicted across subgroups of participants who reported differing amounts of change in breast appearance when their arms were lifted overhead or when they lifted something heavy, and for increasing happiness with the overall outcome of their breast reconstruction.
The 12-item Animation Deformity scale forms a new scale in the BREAST-Q Reconstruction Module that can be used in comparative effectiveness research or to inform clinical care.
为了评估动画畸形对健康相关生活质量的影响，需要使用特定于内容、有效且可靠的患者报告结局测量工具。本报告描述了 BREAST-Q 动画畸形量表的开发和验证。
接受基于植入物的重建的乳腺癌女性提供了数据。在第 1 阶段（2017 年 1 月至 2018 年 12 月），使用定性和认知患者访谈以及专家意见来开发和完善量表内容。在第 2 阶段（2019 年 3 月至 6 月），使用 Love Research Army（LRA）成员进行了现场测试研究。Rasch 测量理论（RMT）分析用于检查心理测量特性。
在研究的第 1 阶段，定性（n=11）和认知（n=4）访谈数据以及专家意见（n=9）导致开发了一个 12 项量表，用于测量动画畸形。在第 2 阶段，651 名 LRA 成员提供了数据，349 名成员参加了重测研究。在 RMT 分析中，数据符合 Rasch 模型（X(96)=104.06;p=0.27）。该量表的可靠性很高，个人分离指数和 Cronbach alpha 值（有无极值）分别为≥0.84 和≥0.92，内部一致性系数为 0.92（95%置信区间，0.90-0.94）。在报告手臂举过头顶或举重物时乳房外观变化程度不同、对乳房重建总体结果的满意度不同的参与者亚组中，动画畸形量表的平均得分如预期的那样有所不同，且随着幸福感的增加而增加。
12 项动画畸形量表形成了 BREAST-Q 重建模块中的一个新量表，可用于比较效果研究或为临床护理提供信息。
