脆性 X 综合征年轻女性：执行功能对神经认知特征和适应行为的影响。

Fragile X syndrome in young females: Influence of executive function on the neurocognitive profile and adaptive behavior.

机构信息

Consorcio Corporación Sanitaria Parc Taulí, Sabadell, Spain; Departamento de Psiquiatría y Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain.

Servicio de Psiquiatría, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Departament de Psicología Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Res Dev Disabil. 2021 May;112:103912. doi: 10.1016/j.ridd.2021.103912. Epub 2021 Feb 24.

DOI:10.1016/j.ridd.2021.103912

PMID:33639603

Abstract

INTRODUCTION

The aim of this study is to describe the relationship between executive function (EF) and performance in different areas of the neurocognitive profile in young girls with Fragile-X-Syndrome (FXS).

METHOD

A neuropsychological assessment was carried out to 40 female participants aged 7-16 years (26 FXS, 14 control group).

RESULTS

Regarding intellectual ability, in the group of girls with FXS 3.84 % of the participants obtained IQ scores in the range of moderate ID (IQ 35-40 to 49), 46.15 % in the range of mild ID (IQ 50-70), 38.46 % in the borderline range (IQ 70-85), and 11.53 % within the average range (IQ > 85). EF was found to have a greater influence on adaptive behavior, arithmetic ability, theory of mind, leadership, social integration, social competence, and anxiety/shyness in the group with FXS.

CONCLUSIONS

In girls with FXS, EF showed a greater influence on adaptive behavior, arithmetic ability, and social domain.

摘要

简介

本研究旨在描述脆性 X 综合征（FXS）年轻女性的执行功能（EF）与神经认知特征不同领域表现之间的关系。

方法

对 40 名 7-16 岁的女性参与者（26 名 FXS，14 名对照组）进行了神经心理学评估。

结果

在 FXS 组的智力能力方面，有 3.84%的参与者的智商得分处于中度智力障碍（智商 35-40 至 49），46.15%处于轻度智力障碍（智商 50-70），38.46%处于边缘范围（智商 70-85），11.53%处于平均范围（智商>85）。EF 对 FXS 组的适应行为、算术能力、心理理论、领导力、社会融合、社会能力和焦虑/害羞有更大的影响。