急性风湿热中 A 组链球菌感染的血清学分析。
Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.
机构信息
School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
出版信息
Clin Infect Dis. 2021 Dec 16;73(12):2322-2325. doi: 10.1093/cid/ciab180.
PMID:33639619
Abstract
Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
摘要
风湿热是 A 组链球菌（GAS）感染后的严重后遗症。先前的 GAS 暴露情况通过使用大量 M 型特异性肽的大型面板在血清中进行了映射。风湿热患者的血清学证据表明，他们经历了比匹配对照组更多的 GAS 暴露，这表明重复感染引起的免疫致敏有助于发病机制。
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