School of Medical Sciences, University of Auckland, Auckland, New Zealand.
Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
Clin Infect Dis. 2021 Dec 16;73(12):2322-2325. doi: 10.1093/cid/ciab180.
Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
风湿热是 A 组链球菌（GAS）感染后的严重后遗症。先前的 GAS 暴露情况通过使用大量 M 型特异性肽的大型面板在血清中进行了映射。风湿热患者的血清学证据表明，他们经历了比匹配对照组更多的 GAS 暴露，这表明重复感染引起的免疫致敏有助于发病机制。
