Children's Hospital of Soochow University, Jiangsu, China AND Department of Pediatrics, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Children's Hospital of Soochow University, Jiangsu, China.
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):1-10. doi: 10.18502/ijaai.v20i1.5407.
Previous studies have reported that T cell immunoglobulin domain and mucin domain-3 (TIM-3) 574T>G and 1516G>T are associated with the risk of asthma. However, the results are inconsistent due to the small sample size and varied age in studies. We performed this meta-analysis to systematically evaluated the effect of TIM-3 574T>G and 1516G>T genetic polymorphisms on asthma. Eligible articles that reported an association between TIM-3 574T>G and 1516G>T genetic polymorphisms and asthma were searched in PubMed, Medline, EMBASE, Google Scholar, and China National Knowledge Infrastructure up to April 2020. Random or fixed-effects models were used to calculate the summary of odds ratios (ORs) and 95% confidence intervals (CIs) to detect any potential associations between TIM-3 genetic polymorphisms and asthma. Subgroup and sensitivity analyses were performed to assess the potential sources of heterogeneity and the robustness of the pooled estimation. Publication bias was analyzed using the Egger test. A total of 11 case-control studies including 2077 asthma patients and 2122 control subjects were finally analyzed (published data form 2004-2018). The pooled results indicated that TIM-3 574T>G genetic polymorphisms were significantly associated with an increased risk of asthma under the dominant model (GG vs. GT +TT: ORs=2.26, 95% CI 1.09-4.69) and allele model (G vs T: ORs=2.60, 95% CI 1.20-5.64). However, no significant associations between TIM-3 1516G>T genetic polymorphisms with asthma in any model was found. No evidence of publication bias was observed. Our study indicates that TIM-3 574T>G genetic polymorphisms were associated with increased risk of asthma and the TIM-3 1516G>T genetic polymorphisms may not be correlated with asthma.
先前的研究报告称，T 细胞免疫球蛋白域和粘蛋白域 3（TIM-3）574T>G 和 1516G>T 与哮喘风险相关。然而，由于研究中样本量小且年龄不同，结果不一致。我们进行了这项荟萃分析，以系统评估 TIM-3 574T>G 和 1516G>T 遗传多态性对哮喘的影响。在 PubMed、Medline、EMBASE、Google Scholar 和中国国家知识基础设施中搜索了截至 2020 年 4 月报道 TIM-3 574T>G 和 1516G>T 遗传多态性与哮喘之间关联的符合条件的文章。使用随机或固定效应模型计算汇总优势比（OR）和 95%置信区间（CI），以检测 TIM-3 遗传多态性与哮喘之间的任何潜在关联。进行亚组和敏感性分析，以评估异质性的潜在来源和汇总估计的稳健性。使用 Egger 检验分析发表偏倚。最终分析了 11 项病例对照研究，包括 2077 例哮喘患者和 2122 例对照（发表数据来自 2004-2018 年）。汇总结果表明，TIM-3 574T>G 遗传多态性在显性模型（GG 与 GT+TT：ORs=2.26，95%CI 1.09-4.69）和等位基因模型（G 与 T：ORs=2.60，95%CI 1.20-5.64）下与哮喘风险增加显著相关。然而，在任何模型中均未发现 TIM-3 1516G>T 遗传多态性与哮喘之间存在显著关联。未发现发表偏倚的证据。我们的研究表明，TIM-3 574T>G 遗传多态性与哮喘风险增加相关，而 TIM-3 1516G>T 遗传多态性可能与哮喘无关。
