Department of Dentistry, Bharathirajaa Hospital, and Research Institute, Chennai, India.
Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
Dis Mon. 2021 Sep;67(9):101168. doi: 10.1016/j.disamonth.2021.101168. Epub 2021 Feb 24.
Human immunodeficiency virus-infected patients have depleted CD4 lymphocyte counts and are susceptible to a plethora of infections of bacterial, viral, and fungal etiology. In addition to a wide range of systemic manifestations, human immunodeficiency virus-infected patients also display several characteristic oral manifestations. Studies have shown a correlation between some of the oral manifestations and CD4 lymphocyte counts which in turn is an independent prognostic indicator. To tackle the human immunodeficiency virus numerous drugs have been discovered and implemented. To overcome any potential resistance, human immunodeficiency virus patients are prescribed highly active antiretroviral therapy, wherein a combination of antiretroviral regimens are used. Studies have shown that in addition to controlling the viral activity, the treatment regimen, has a significant effect on the oral manifestations of the human immunodeficiency virus-infected patients. The present paper highlights the effects of highly active antiretroviral therapy on periodontal diseases in human immunodeficiency virus-infected individuals.
人类免疫缺陷病毒感染患者的 CD4 淋巴细胞计数减少，容易受到多种细菌、病毒和真菌感染的影响。除了广泛的全身表现外，人类免疫缺陷病毒感染患者还表现出几种特征性的口腔表现。研究表明，一些口腔表现与 CD4 淋巴细胞计数之间存在相关性，而 CD4 淋巴细胞计数又是一个独立的预后指标。为了应对人类免疫缺陷病毒，已经发现并实施了许多药物。为了克服任何潜在的耐药性，人类免疫缺陷病毒患者被开处高效抗逆转录病毒疗法，其中使用抗逆转录病毒方案的组合。研究表明，除了控制病毒活性外，治疗方案对人类免疫缺陷病毒感染患者的口腔表现也有显著影响。本文重点介绍了高效抗逆转录病毒疗法对人类免疫缺陷病毒感染者牙周病的影响。
