Ndouga S E, Poka-Mayap V, Dodo Balkissou A, Djenabou A, Kuaban A, Haman A, Ofimboudem-Nguetsa A, Sobngwi E, Pefura-Yone E W
Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Pulmonology unit, Yaoundé Jamot Hospital, Yaoundé, Cameroon.
Respir Med Res. 2021 May;79:100816. doi: 10.1016/j.resmer.2021.100816. Epub 2021 Feb 5.
The objective of this study was to assess the association between spirometric restrictive ventilatory pattern (sRVP) and type 2 diabetes mellitus (T2DM) and investigate factors associated with sRVP in subjects with T2DM.
In this comparative cross-sectional study, subjects with T2DM (diabetes group) were compared to a group of subjects without diabetes (non-diabetes group) from December 2018 to March 2019 (4months) at the National Obesity Center of the Yaoundé Central Hospital. sRVP was defined as the ratio of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) above the lower limit of normal, and FVC<80% of predicted values. Logistic regression was used to identify factors associated with sRVP.
Overall 277 subjects were included in each group. The prevalence [95% confidence interval (95% CI)] of sRVP in the diabetes and non-diabetes groups was 39.4 (33.6-45.1) % and 34.3 (28.9-40.1) %, P=0.218. After multivariate analysis, we did not find an independent association between s sRVP and T2DM [odds ratio (95% CI): 1.13 (0.79-1.63), P=0.418]. The only independent factor associated with sRVP in subjects with T2DM was the presence of chronic vascular complications [odds ratio (95% CI): 1.99 (1.11-3.55), P=0.019].
One-third of patients with type 2 diabetes mellitus have sRVP. There is no independent association between sRVP and T2DM. The presence of chronic vascular complications is associated with sRVP in T2DM. Diagnosis of sRVP in subjects with T2DM presenting chronic vascular complications would help to provide a holistic management.
本研究的目的是评估肺量计限制性通气模式（sRVP）与2型糖尿病（T2DM）之间的关联，并调查T2DM患者中与sRVP相关的因素。
在这项比较性横断面研究中，于2018年12月至2019年3月（4个月）期间，在雅温得中心医院国家肥胖中心，将T2DM患者（糖尿病组）与一组无糖尿病的患者（非糖尿病组）进行比较。sRVP定义为一秒用力呼气量（FEV1）与用力肺活量（FVC）之比高于正常下限，且FVC<预测值的80%。采用逻辑回归来确定与sRVP相关的因素。
每组共纳入277名受试者。糖尿病组和非糖尿病组sRVP的患病率[95%置信区间（95%CI）]分别为39.4（33.6 - 45.1）%和34.3（28.9 - 40.1）%，P = 0.218。多变量分析后，我们未发现sRVP与T2DM之间存在独立关联[比值比（95%CI）：1.13（0.79 - 1.63），P = 0.418]。T2DM患者中与sRVP相关的唯一独立因素是存在慢性血管并发症[比值比（95%CI）：1.99（1.11 - 3.55），P = 0.019]。
三分之一的2型糖尿病患者有sRVP。sRVP与T2DM之间不存在独立关联。慢性血管并发症的存在与T2DM中的sRVP相关。对存在慢性血管并发症的T2DM患者诊断sRVP将有助于提供全面管理。
