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[缓慢进展型精神分裂症与癔症型精神变态的临床-系谱比较分析]

[Comparative clinico-genealogical analysis of slowly progressive schizophrenia and hysterical-type psychopathy].

作者信息

Dubnitskaia E B, Fil'ts A O, Chernikova T S

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(1):56-61.

PMID:3364099
Abstract

A genetic correlational analysis of two variants of slowly progressive schizophrenia (SPS) (hysterical schizophrenia--70 families, paranoid schizophrenia--40 families) and hysterical psychopathy (30 families) has demonstrated that there is a definite genetic heterogeneity between nosologically heterogeneous hysterical manifestations in SPS and constitutional psychopathy which reflects the influence of the general constitutional "axis" in systems of genetic determination of these forms. At the same time no significant genetic correlations (according to hysterical predisposition) have been found between the above forms and the paranoid variant of SPS. The results corroborate the hypothesis about a multiaxial structure of hereditary predisposition in SPS.

摘要

对缓慢进行性精神分裂症(SPS)的两种变体(癔症型精神分裂症——70个家庭,偏执型精神分裂症——40个家庭)以及癔症型精神病(30个家庭)进行的基因相关性分析表明,SPS中病因学上异质的癔症表现与体质性精神病之间存在明确的基因异质性,这反映了在这些形式的基因决定系统中一般体质“轴”的影响。同时,在上述形式与SPS的偏执型变体之间未发现显著的基因相关性(根据癔症易感性)。结果证实了关于SPS遗传易感性多轴结构的假说。

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