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胃肠道神经内分泌肿瘤的个体化治疗。

Treatment personalization in gastrointestinal neuroendocrine tumors.

机构信息

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

出版信息

Curr Treat Options Oncol. 2021 Feb 27;22(4):29. doi: 10.1007/s11864-021-00825-4.

DOI:10.1007/s11864-021-00825-4
PMID:33641005
Abstract

The clinical scenario of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is continuously changing due to significant improvements in the definition of their molecular landscapes and the introduction of innovative therapeutic approaches. Many efforts are currently employed in the integration of the genetics/epigenetics and clinical information. This is leading to an improvement of tumor classification, prognostic stratification and ameliorating the management of patients based on a personalized approach.

摘要

胃肠胰神经内分泌肿瘤(GEP-NENs)的临床情况因分子图谱定义的显著改善和创新治疗方法的引入而不断变化。目前,许多人致力于整合遗传学/表观遗传学和临床信息。这正在导致肿瘤分类、预后分层的改善,并基于个性化方法改善患者的管理。

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Lancet Oncol. 2020 Sep;21(9):e431-e443. doi: 10.1016/S1470-2045(20)30323-5.
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Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs).胃肠胰神经内分泌肿瘤(GEP-NENs)的全面基因组分析。
Clin Cancer Res. 2020 Nov 15;26(22):5943-5951. doi: 10.1158/1078-0432.CCR-20-1804. Epub 2020 Sep 3.
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Targeting CD73 to augment cancer immunotherapy.
Epidemiology of Neuroendocrine Neoplasms and Results of Their Treatment with [Lu]Lu-DOTA-TATE or [Lu]Lu-DOTA-TATE and [Y]Y-DOTA-TATE-A Six-Year Experience in High-Reference Polish Neuroendocrine Neoplasm Center.
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