Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India; Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India.
Crit Rev Oncog. 2021;26(1):21-33. doi: 10.1615/CritRevOncog.2020035666.
Liver cancer (LC) is the most common high-mortality malignancy, due to its aggressive nature, heterogeneity, and metastasis. Recent studies have recognized long noncoding RNAs (lncRNAs) as mediators of LC pathogenesis and metastasis. This review describes the role of lncRNAs in molecular mechanisms of tumorigenicity, metastasis, stem-cell maintenance, drug resistance, and tumor immunity. We present recent updates on therapeutic targeting of lncRNAs in LC as well as lncRNA's potential for LC diagnosis. Overall, we provide a new perspective on the role of lncRNAs for LC treatment and diagnosis.
肝癌（LC）是最常见的高死亡率恶性肿瘤，由于其侵袭性、异质性和转移性。最近的研究已经认识到长非编码 RNA（lncRNAs）作为 LC 发病机制和转移的介质。本综述描述了 lncRNAs 在肿瘤发生、转移、干细胞维持、耐药性和肿瘤免疫的分子机制中的作用。我们介绍了 lncRNAs 在 LC 治疗中的靶向治疗的最新进展以及 lncRNA 在 LC 诊断中的潜在应用。总的来说，我们为 lncRNAs 在 LC 的治疗和诊断中的作用提供了新的视角。
