National Infection Service, Public Health England, London, UK.
National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections, Liverpool, UK.
Epidemiol Infect. 2021 Mar 1;149:e71. doi: 10.1017/S0950268821000509.
In April 2018, Public Health England was notified of cases of Shigella sonnei who had eaten food from three different catering outlets in England. The outbreaks were initially investigated as separate events, but whole-genome sequencing (WGS) showed they were caused by the same strain. The investigation included analyses of epidemiological data, the food chain and microbiological examination of food samples. WGS was used to determine the phylogenetic relatedness and antimicrobial resistance profile of the outbreak strain. Ultimately, 33 cases were linked to this outbreak; the majority had eaten food from seven outlets specialising in Indian or Middle Eastern cuisine. Five outlets were linked to two or more cases, all of which used fresh coriander although a shared supplier was not identified. An investigation at one of the venues recorded that 86% of cases reported eating dishes with coriander as an ingredient or garnish. Four cases were admitted to hospital and one had evidence of treatment failure with ciprofloxacin. Phylogenetic analysis showed that the outbreak strain was part of a wider multidrug-resistant clade associated with travel to Pakistan. Poor hygiene practices during cultivation, distribution or preparation of fresh produce are likely contributing factors.
2018 年 4 月，英国公共卫生部接到报告，称有几例宋内志贺氏菌感染病例，这些病例均食用过英格兰三个不同餐饮点的食物。这些疫情起初被调查为独立事件，但全基因组测序（WGS）显示它们是由同一菌株引起的。调查包括对流行病学数据、食物链和食物样本微生物学检测的分析。WGS 用于确定疫情菌株的系统发育关系和抗药性特征。最终，有 33 例病例与此次疫情有关；大多数病例食用了 7 家专门供应印度或中东美食的餐馆的食物。有 5 家餐馆与 2 例或更多病例有关，所有这些餐馆都使用了新鲜的芫荽，但没有发现共同的供应商。在其中一个场所的调查记录显示，86%的病例报告食用了含有芫荽作为配料或装饰的菜肴。有 4 例病例住院治疗，其中 1 例因环丙沙星治疗失败而出现证据。系统发育分析显示，疫情菌株是与前往巴基斯坦旅行有关的更广泛的多药耐药群的一部分。在新鲜农产品的种植、配送或准备过程中卫生条件差，可能是造成这一问题的因素。
