[Effect of monoamine levels on gonadotropin releasing hormone concentration in the hypothalamus, pituitary gonadotropic fuction and ovarian ovulatory and hormonal function].

Daily administration of 0.25 mg reserpine during 14 days reduces the noradrenaline and dopamine level in the hypothalamus by 21--47 per cent and the LH level in the blood. The amount of Gn-RH in the supra-and retrochiasmatic portions of the hypothalamus is significantly increased thereby indicating an inhibition of the RH release into the blood of portal vein. The same course of 0.5--0.75 mg reserpine reduces the level of catecholamines by 51--82 per cent, the Gn-Rh content decreasing in the preoptic, supra-and retrochiasmatic areas along with further decrease of LH level in the blood. This is due, probably, to disturbance of both synthesis and release of Gn-RH. Consequently, the catecholamines activate primarily the release and then the synthesis of Gn-RH. The level of gonadotropins in hypophysis undergoes no essential alterations under the influence of reserpine, the animals develop a constant diestrus, great major yellow bodies appearing in the ovaires while the number of folliculi reduces. The hormonal activity of ovaries at that (secretion of estrogens and progesterone) decreases.