CSIR-Institute of Genomics and Integrative Biology, Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
CSIR-Institute of Genomics and Integrative Biology, Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Adv Genet. 2021;107:1-32. doi: 10.1016/bs.adgen.2020.11.001. Epub 2021 Feb 2.
While asthma has a strong genetic component, our current ability to systematically understand and predict asthma risk remains low, despite over a hundred genetic associations. The reasons for this unfilled gap range from technical limitations of current approaches to fundamental deficiencies in the way we understand asthma. These are discussed in the context of genomic advances.
虽然哮喘有很强的遗传成分，但尽管已经有超过一百个遗传关联，我们目前系统性地理解和预测哮喘风险的能力仍然很低。造成这种未满足差距的原因从当前方法的技术局限性到我们理解哮喘的方式的根本缺陷都有。这些内容是在基因组学进展的背景下进行讨论的。
