Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avd. Reina Mercedes, Sevilla, Spain.
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avd. Reina Mercedes, Sevilla, Spain.
Adv Genet. 2021;107:33-87. doi: 10.1016/bs.adgen.2020.11.002. Epub 2020 Dec 8.
Developmental programs are under strict genetic control that favors robustness of the process. In order to guarantee the same outcome in different environmental situations, development is modulated by input pathways, which inform about external conditions. In the nematode Caenorhabditis elegans, the process of postembryonic development involves a series of stereotypic cell divisions, the progression of which is controlled by the nutritional status of the animal. C. elegans can arrest development at different larval stages, leading to cell arrest of the relevant divisions of the stage. This means that studying the nutritional control of development in C. elegans we can learn about the mechanisms controlling cell division in an in vivo model. In this work, we reviewed the current knowledge about the nutrient sensing pathways that control the progression or arrest of development in response to nutrient availability, with a special focus on the arrest at the L1 stage.
发育程序受到严格的遗传控制，有利于该过程的稳健性。为了保证在不同的环境情况下有相同的结果，发育受到输入途径的调节，这些输入途径可以提供关于外部条件的信息。在秀丽隐杆线虫中，胚胎后发育过程涉及一系列定型的细胞分裂，其进展受动物营养状况的控制。秀丽隐杆线虫可以在不同的幼虫阶段停止发育，导致该阶段相关分裂的细胞停止。这意味着，通过研究秀丽隐杆线虫中发育的营养控制，我们可以了解控制体内模型中细胞分裂的机制。在这项工作中，我们综述了目前关于营养感应途径的知识，这些途径控制着发育的进展或停止，以响应营养的可用性，特别关注 L1 阶段的停止。
