锝-99 聚合白蛋白计划与治疗后钇-90 内转换电子发射断层扫描/计算机断层扫描的肿瘤与正常比值关系。
Tumor-to-Normal Ratio Relationship between Planning Technetium-99 Macroaggregated Albumin and Posttherapy Yttrium-90 Bremsstrahlung SPECT/CT.
机构信息
Department of Radiology and Imaging Sciences, Atlanta, Georgia.
Department of Radiology and Imaging Sciences, Atlanta, Georgia.
出版信息
J Vasc Interv Radiol. 2021 May;32(5):752-760. doi: 10.1016/j.jvir.2020.12.023. Epub 2021 Feb 26.
PURPOSE
To quantify the relationship of the tumor-to-normal ratio (TNR) attained from the technetium-99m macroaggregated albumin (MAA) and posttreatment yttrium-90 bremsstrahlung (Y90-Brem) single-photon emission computerized tomography (SPECT)/computer tomography (CT) studies in patients with hepatocellular carcinoma (HCC) treated with glass microspheres.
MATERIALS AND METHODS
Retrospectively, a total of 190 consecutive patients with HCC who underwent 204 MAA and Y90-Brem SPECT/CT for glass microsphere Y90 radiation segmentectomy (Y90-RS) or lobar treatment (Y90-RLT) between 2013 and 2018 were included. Semi-automated regions-of-interests were drawn around the targeted tumor and nontumoral liver tissue on the SPECT/CT studies. TNR values from MAA and Y90-Brem SPECT/CT were compared using paired t-tests, Pearson correlation, and median with interquartile ranges (IQR).
RESULTS
The mean TNR for MAA and Y90-Brem SPECT/CT was 2.96 ± 1.86 (median, 2.64; IQR, 2.50) and 2.29 ± 1.10 (median, 2.06; IQR, 1.05), respectively (P < .0001). The mean Y90-RLT TNR was 2.88 ± 1.67 (median, 2.59; IQR, 0.83) and 2.17 ± 0.89 (median, 1.98; IQR, 0.81) for MAA and Y90-Brem SPECT/CT, respectively (P < .0001). The mean Y90-RS TNR was 3.02 ± 2.01 (median, 2.87; IQR, 3.01) and 2.39 ± 1.25 (median, 2.11; IQR, 1.28) for MAA and Y90-Brem SPECT/CT, respectively (P = .0003). TNR attained from MAA and Y90 SPECT/CT studies showed a moderate correlation in a positive linear fashion for the overall (r = 0.54; P < .001), Y90-RLT (r = 0.66, P < .001), and Y90-RS cohorts (r = 0.48, P < .001).
CONCLUSIONS
The TNR attained from Y90-Brem SPECT/CT is often underestimated, positively correlated, and less variable than that attained from MAA SPECT/CT.
目的
定量分析锝-99m 聚合白蛋白（MAA）肿瘤与正常比值（TNR）与钇-90 放射性玻璃微球布雷斯特辐射（Y90-Brem）单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）在肝细胞癌（HCC）患者中的关系，这些患者接受了玻璃微球 Y90 放射性切除术（Y90-RS）或叶治疗（Y90-RLT）。
材料与方法
回顾性分析了 2013 年至 2018 年间共 190 例接受 MAA 和 Y90-Brem SPECT/CT 的 HCC 患者，共进行了 204 次玻璃微球 Y90 辐射切除术（Y90-RS）或叶治疗（Y90-RLT）。在 SPECT/CT 研究中，使用半自动感兴趣区（ROI）描记肿瘤和非肿瘤肝组织。使用配对 t 检验、Pearson 相关和中位数（四分位数间距）比较 MAA 和 Y90-Brem SPECT/CT 的 TNR 值。
结果
MAA 和 Y90-Brem SPECT/CT 的平均 TNR 分别为 2.96 ± 1.86（中位数，2.64；四分位数间距，2.50）和 2.29 ± 1.10（中位数，2.06；四分位数间距，1.05）（P<0.0001）。MAA 和 Y90-Brem SPECT/CT 中 Y90-RLT 的平均 TNR 分别为 2.88 ± 1.67（中位数，2.59；四分位数间距，0.83）和 2.17 ± 0.89（中位数，1.98；四分位数间距，0.81）（P<0.0001）。MAA 和 Y90-Brem SPECT/CT 中 Y90-RS 的平均 TNR 分别为 3.02 ± 2.01（中位数，2.87；四分位数间距，3.01）和 2.39 ± 1.25（中位数，2.11；四分位数间距，1.28）（P=0.0003）。MAA 和 Y90 SPECT/CT 研究中获得的 TNR 呈正线性相关，整体呈中度相关（r=0.54；P<0.001），Y90-RLT（r=0.66，P<0.001）和 Y90-RS 队列（r=0.48，P<0.001）。
结论
Y90-Brem SPECT/CT 获得的 TNR 往往被低估，与 MAA SPECT/CT 相比，呈正相关且变异性更小。
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