Murakami Ryo, Inagaki Fuyuhiko
The Faculty of Pharmaceutical Science, Kobe Gakuin University.
Yakugaku Zasshi. 2021;141(3):305-314. doi: 10.1248/yakushi.20-00179-1.
The interaction between transition metals and ligands is important for catalytic reactions. The ligands are largely dominated by the covalent X-type (hydride, alkyl and halogen) and/or dative L-type ligands (e.g., P, N, CO, olefin, etc.). Therefore, the interaction of the Z-type ligands (B, Al and Si, etc.) with transition metals is emerging as a new concept for the reactivity of the metal center. Recently, we developed the synthesis of the gold complex Au(DPB)X (DPB=diphosphine-borane) featuring the Z-type ligand, and their catalytic reaction. The gold catalysts showed a high activity compared to the general catalysts (without Z-ligand) for the various cyclization reactions due to the electron-withdrawing effect of the Z-ligand on the coordinating gold center. In this review, first the structure analysis of the synthesized Au→Z complex is introduced in detail, and second, the catalytic reactions based on the alkyne activation are described.
过渡金属与配体之间的相互作用对于催化反应很重要。配体在很大程度上由共价X型（氢化物、烷基和卤素）和/或给予型L型配体（例如P、N、CO、烯烃等）主导。因此，Z型配体（B、Al和Si等）与过渡金属的相互作用正作为金属中心反应性的一个新概念而出现。最近，我们开发了具有Z型配体的金配合物Au(DPB)X（DPB = 二膦硼烷）的合成及其催化反应。由于Z型配体对配位金中心的吸电子作用，与普通催化剂（不含Z配体）相比，金催化剂在各种环化反应中表现出高活性。在这篇综述中，首先详细介绍了合成的Au→Z配合物的结构分析，其次描述了基于炔烃活化的催化反应。
