氧分压对犬颈动脉平滑肌膜电位和张力的影响。

The influence of oxygen tension on membrane potential and tone of canine carotid artery smooth muscle.

作者信息

Grote J, Siegel G, Zimmer K, Adler A

机构信息

Institute of Physiology I, University of Bonn, Germany.

出版信息

Adv Exp Med Biol. 1988;222:481-7. doi: 10.1007/978-1-4615-9510-6_57.

DOI:10.1007/978-1-4615-9510-6_57

PMID:3364274

Abstract

In vascular smooth muscle of canine carotid artery segments the decrease in oxygen tension from approximately 550 mmHg to approximately 30 mmHg leads to a dose-dependent hyperpolarization and relaxation of the vessel strip. At PO2 values below approximately 15-20 mmHg depolarization and subsequent contraction were found. All changes of the parameters investigated were reversible. Indomethacin (10(-5) M) had no significant effect on the hypoxia-dependent potential and tension changes. The hyperpolarized part of the activation curve was obtained by plotting tension versus membrane potential values.

摘要

在犬颈动脉段的血管平滑肌中，氧张力从约550 mmHg降至约30 mmHg会导致血管条带出现剂量依赖性超极化和舒张。在PO2值低于约15 - 20 mmHg时，发现有去极化及随后的收缩。所研究参数的所有变化都是可逆的。吲哚美辛（10(-5) M）对缺氧依赖性电位和张力变化无显著影响。通过绘制张力与膜电位值的关系得到激活曲线的超极化部分。