Wakumoto Keiko, Sugita Kazunari, Yamamoto Osamu
Division of Dermatology, Matsue Red Cross Hospital, Matsue 690-0886, Japan and.
Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Yonago Acta Med. 2020 Dec 25;64(1):126-128. doi: 10.33160/yam.2021.02.006. eCollection 2021 Feb.
We report a case of subcutaneous panniculitis-like T-cell lymphoma with diffuse indurated lesions without erythema. A 27-year-old man was referred to us with a 1-month history of fever, general fatigue and indurated skin lesions. The initial examination revealed indurated skin lesions without erythema and subcutaneous tumors in the right lower abdomen, back and buttocks. Histopathology showed a panniculitis predominantly in lobular pattern, and infiltration of atypical lymphocytes in the subcutaneous tissue. Characteristically, there was rimming of individual fat cells by surrounding atypical lymphocytes. Results of laboratory examinations showed hemophagocytic syndrome (HPS). Based on these findings, we made a diagnosis of subcutaneous panniculitis-like T-cell lymphoma without erythema and subcutaneous tumors with HPS. To our knowledge, there has been no report of SPTCL with diffuse indurated lesions without erythema, tumors, or plaque, all of which are considered to be typical characteristics of SPTCL. Positron emission tomography / computed tomography (PET/CT) showed noticeable thickening of diffuse subcutaneous involvement throughout the body. Hence, PET/CT is a useful for the detection of SPTCL as well as its distribution.
我们报告一例皮下脂膜炎样T细胞淋巴瘤,表现为弥漫性硬结性病变且无红斑。一名27岁男性因发热、全身乏力及皮肤硬结性病变1个月前来就诊。初诊检查发现右下腹部、背部及臀部有无红斑的硬结性皮肤病变及皮下肿物。组织病理学显示主要为小叶型脂膜炎,皮下组织有非典型淋巴细胞浸润。其特征为单个脂肪细胞被周围非典型淋巴细胞包绕。实验室检查结果显示存在噬血细胞综合征(HPS)。基于这些发现,我们诊断为无红斑及皮下肿物的皮下脂膜炎样T细胞淋巴瘤伴HPS。据我们所知,此前尚无关于皮下脂膜炎样T细胞淋巴瘤表现为弥漫性硬结性病变且无红斑、肿物或斑块的报道,而这些均被认为是皮下脂膜炎样T细胞淋巴瘤的典型特征。正电子发射断层扫描/计算机断层扫描(PET/CT)显示全身弥漫性皮下受累明显增厚。因此,PET/CT对于皮下脂膜炎样T细胞淋巴瘤的检测及其分布情况很有用。