Langerak Thomas, van Rooij Irene, Doornekamp Laura, Chandler Felicity, Baptista Mark, Yang Harvey, Koopmans Marion P G, GeurtsvanKessel Corine H, Jacobs Bart C, Rockx Barry, Adriani Kirsten, van Gorp Eric C M
Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Department of Neurology, St. Vincentius Hospital, Paramaribo, Suriname.
Front Neurol. 2021 Feb 10;12:635753. doi: 10.3389/fneur.2021.635753. eCollection 2021.
Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname.
吉兰-巴雷综合征（GBS）与包括巨细胞病毒在内的多种先前感染有关，但也与热带地区流行的节肢动物传播病毒（虫媒病毒）有关，如寨卡病毒。在此，我们呈现了2016年初至2018年年中在苏里南住院的12例GBS患者的临床特征。针对通常与GBS相关的病原体以及虫媒病毒进行了广泛的诊断检测，以确定可能导致GBS的先前感染。通过这种广泛的检测算法，我们在6例患者中识别出近期感染，其中4例有近期寨卡病毒或登革病毒感染的证据。这些结果表明，虫媒病毒，特别是寨卡病毒，但也可能包括登革病毒，可能是苏里南GBS的重要致病因素。此外，我们发现静脉注射免疫球蛋白或血浆置换的更多可及性可能会改善苏里南GBS的治疗。
