Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Front Immunol. 2021 Feb 10;11:620170. doi: 10.3389/fimmu.2020.620170. eCollection 2020.
The human intestine contains thousands of bacterial species essential for optimal health. Aside from their pathogenic effects, these bacteria have been associated with the efficacy of various treatments of diseases. Due to their impact on many human diseases, intestinal bacteria are receiving increasing research attention, and recent studies on intestinal bacteria and their effects on treatments has yielded valuable results. Particularly, intestinal bacteria can affect responses to numerous forms of immunotherapy, especially cancer therapy. With the development of precision medicine, understanding the factors that influence intestinal bacteria and how they can be regulated to enhance immunotherapy effects will improve the application prospects of intestinal bacteria therapy. Further, biomaterials employed for the convenient and efficient delivery of intestinal bacteria to the body have also become a research hotspot. In this review, we discuss the recent findings on the regulatory role of intestinal bacteria in immunotherapy, focusing on immune cells they regulate. We also summarize biomaterials used for their delivery.
人类肠道中含有数千种对健康至关重要的细菌物种。除了它们的致病作用外，这些细菌还与各种疾病治疗的疗效有关。由于它们对许多人类疾病的影响，肠道细菌越来越受到研究关注，最近关于肠道细菌及其对治疗影响的研究取得了有价值的结果。特别是，肠道细菌可以影响对多种形式免疫疗法的反应，尤其是癌症治疗。随着精准医学的发展，了解影响肠道细菌的因素以及如何调节它们以增强免疫疗法效果，将提高肠道细菌治疗的应用前景。此外，用于方便有效地将肠道细菌递送到体内的生物材料也成为一个研究热点。在本文综述中，我们讨论了肠道细菌在免疫疗法中的调节作用的最新发现，重点是它们调节的免疫细胞。我们还总结了用于其递送的生物材料。
