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空气污染与分枝杆菌生物气溶胶的空气传播感染:烟尘的潜在归因。

Air pollution and airborne infection with mycobacterial bioaerosols: a potential attribution of soot.

作者信息

Noda J, Tomizawa S, Takahashi K, Morimoto K, Mitarai S

机构信息

School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido Japan.

Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.

出版信息

Int J Environ Sci Technol (Tehran). 2022;19(2):717-726. doi: 10.1007/s13762-021-03203-7. Epub 2021 Feb 21.

Abstract

Atmospheric pollutants are hypothesized to enhance the viability of airborne microbes by preventing them from degradation processes, thereby enhancing their atmospheric survival. In this study, is used as a model airborne bacteria, and different amounts of soot particles are employed as model air pollutants. The toxic effects of soot on aerosolized are first evaluated and excluded by introducing them separately into a chamber, being sampled on a filter, and then cultured and counted. Secondly, the bacteria-soot mixture is exposed to UV with different durations and then cultured for bacterial viability evaluations. The results show that under UV exposure, the survival rates of the low-, medium-, and high-soot groups are 1.1 (±0.8) %, 70.9 (±4.3) %, and 61.0 (±17.6) %, respectively. This evidence significantly enhanced survival rates by soot at all UV exposures, though the combinations of UV exposure and soot amounts revealed a changing pattern of survival rates. The possible influence by direct and indirect effects of UV-damaging mechanisms is proposed. This study indicates the soot-induced survival rate enhancements of under UV stress conditions, representing the possible relations between air pollution and the extended pathogenic viability and, therefore, increased airborne infection probability.

摘要

大气污染物被假定为通过阻止空气传播微生物的降解过程来提高其生存能力,从而增强它们在大气中的存活能力。在本研究中,[具体细菌名称未给出]被用作空气传播细菌的模型,不同数量的烟尘颗粒被用作空气污染物的模型。首先,通过将烟尘分别引入一个腔室,在滤膜上进行采样,然后进行培养和计数,来评估并排除烟尘对雾化[具体细菌名称未给出]的毒性作用。其次,将细菌 - 烟尘混合物暴露于不同时长的紫外线下,然后进行培养以评估细菌的生存能力。结果表明,在紫外线照射下,低烟尘组、中烟尘组和高烟尘组的存活率分别为1.1(±0.8)%、70.9(±4.3)%和61.0(±17.6)%。这一证据表明,在所有紫外线照射条件下,烟尘均显著提高了存活率,尽管紫外线照射时长和烟尘量的组合呈现出存活率的变化模式。研究提出了紫外线损伤机制的直接和间接效应可能产生的影响。本研究表明了在紫外线应激条件下,烟尘可提高[具体细菌名称未给出]的存活率,这代表了空气污染与延长的致病生存能力之间可能存在的关系,因此也增加了空气传播感染的概率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1551/7897364/3e721638be1a/13762_2021_3203_Fig1_HTML.jpg

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