Yuan Yan, Yao Shuang, Luo Guang-Hua, Zhang Xiao-Ying
Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
World J Clin Cases. 2021 Feb 26;9(6):1318-1328. doi: 10.12998/wjcc.v9.i6.1318.
During surgery for gastric cancer, peritoneal lavage using warm distilled water can cause temporary hemodynamic changes.
To examine the associations between changes in heart rate and single nucleotide polymorphisms (SNPs).
This was a prospective observational study of patients with gastric cancer who underwent gastrectomy and peritoneal hypotonic lavage at the Third Affiliated Hospital of Soochow University from March 2018 to March 2019. Related SNPs were selected, and the verified exons were analyzed. Heart rate and blood pressure (BP) were measured before and after lavage. The patients were grouped as heart rate change ≥ 30% < 30%. Comparison and regression analyses of the selected SNPs were performed between the two groups.
According to the inclusion/exclusion criteria, 194 patients were included in the analysis. Of these patients, 138 were male, with a mean age of 65.9 ± 0.8 years, and 56 were female, with a mean age of 65.0 ± 1.3 years. Heart rate dropped by 0%-10% in 65 participants, by 10%-15% in 29, by 15%-20% in 23, by 20%-50% in 39, by 50%-100% in four, six had a cardiac arrest, and 28 had an increase in heart rate. Considering the possible impact of exonic SNPs on the phenotypes, TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) were analyzed. The haplotype analysis suggested that the haplotypes CTT [odds ratio (OR) = 2.018, 95% confidence interval (CI): 1.012-4.025, = 0.0430] and GCC (OR = 2.293, 95%CI: 1.174-4.477, = 0.0131) of TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) increased the risk of a drop in heart rate > 30%.
The TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) SNPs were associated with changes in heart rate ≥ 30% during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer.
在胃癌手术期间，使用温蒸馏水进行腹腔灌洗可导致暂时的血流动力学变化。
研究心率变化与单核苷酸多态性（SNP）之间的关联。
这是一项对2018年3月至2019年3月在苏州大学附属第三医院接受胃切除术和腹腔低渗灌洗的胃癌患者进行的前瞻性观察研究。选择相关SNP，并对已验证的外显子进行分析。在灌洗前后测量心率和血压（BP）。将患者分为心率变化≥30%组和<30%组。对两组之间选择的SNP进行比较和回归分析。
根据纳入/排除标准，194例患者纳入分析。其中男性138例，平均年龄65.9±0.8岁；女性56例，平均年龄65.0±1.3岁。65名参与者的心率下降0%-10%，29名下降10%-15%，23名下降15%-20%，39名下降20%-50%，4名下降50%-100%，6名发生心脏骤停，28名心率增加。考虑到外显子SNP对表型的可能影响，对TEP1（rs938886）、TEP1（rs1713449）和RECQL5（rs820196）进行了分析。单倍型分析表明，TEP1（rs938886）、TEP1（rs1713449）和RECQL5（rs820196）的单倍型CTT[比值比（OR）=2.018，95%置信区间（CI）：1.012-至4.025，P=0.0430]和GCC（OR=2.293，95%CI：1.174-4.477，P=0.0131）增加了心率下降>30%的风险。
TEP1（rs938886）、TEP1（rs1713449）和RECQL5（rs820196）SNP与胃癌胃切除术后使用蒸馏水进行腹腔灌洗期间心率变化≥30%相关。
