Curcio A C, Wolpowitz A, Barnard M S, Hassoulas J, Barnard C N
G Ital Cardiol. 1977;7(11):1098-104.
Ten patients, all men, have been operated of heterotopic heart transplantation since the end of 1974. Ages ranged from 59 to 24 years with an average of 38 years. Six of them suffered from ischaemic heart disease, two from cardiomiopathy and two from rheumatic heart disease. All of them presented end stage cardiac disease. The first two patients underwent to left ventricular bypass only, in the remaining eight a right and left bypass was performed. At the present time, June 1977, 6 of the original 10 patients are alive all of them in functional class I. Five of them have resumed a full time job, the sixth will be soon able to do so. Four patients died. There were no deaths from acute rejection, but three died from infection, and the fourth one from a pulmonary embolus, 4 months after transplantation. There has been only one episode of acute rejection which has responded well to the treatment. The advantages of the heterotopic versus the orthotopic cardiac transplantation are discussed.
自1974年底以来,已有10例患者接受了异位心脏移植手术,均为男性。年龄在24岁至59岁之间,平均年龄为38岁。其中6例患有缺血性心脏病,2例患有心肌病,2例患有风湿性心脏病。他们均表现为终末期心脏病。前两位患者仅接受了左心室旁路手术,其余8例进行了左右旁路手术。截至1977年6月,最初的10例患者中有6例存活,所有患者的心功能均为I级。其中5例已恢复全职工作,第6例很快也能恢复。4例患者死亡。没有因急性排斥反应死亡的病例,但3例死于感染,第4例在移植后4个月死于肺栓塞。仅发生过一次急性排斥反应,治疗效果良好。本文讨论了异位心脏移植与原位心脏移植相比的优势。