Sharkey Aidan, Munoz Acuna Ronny, Belani Kiran, Sharma Ravi K, Chaudhary Omar, Fatima Huma, Laham Roger, Mahmood Feroze
Department of Anesthesia, Critical Care and Pain Medicine. Beth Israel Deaconess Medical Center, Harvard Medical School, One, Deaconess Road, Boston, MA 02215, USA.
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Eur Heart J Case Rep. 2020 Dec 28;5(1):ytaa428. doi: 10.1093/ehjcr/ytaa428. eCollection 2021 Jan.
Severe tricuspid regurgitation (TR) is a complex condition that can be difficult to treat medically, and often surgical intervention is prohibited due to the high morbidity and mortality associated with this intervention. In patients who have failed maximal medical therapy and have progressive symptoms related to their severe TR, heterotopic caval valve implantation (CAVI) offers potential for symptom relief for these patients.
We present two cases of patients with severe TR with symptoms of heart failure that were refractory to medical therapy. Due to extensive comorbidities in these patient's surgical intervention was deemed unsuitable and the decision was made to proceed with heterotopic CAVI in order to try and control their symptoms. Both patients successfully underwent the procedure and had an Edwards SAPIEN 3 valve (Edwards Lifesciences, Irvine, CA, USA) implanted in the inferior vena cava/right atrium junction. In both patients, there was improvement in the postoperative haemodynamics as measured by invasive and non-invasive methods. Successful discharge was achieved in both patients with improvement in their symptoms.
Selective use of heterotopic CAVI to treat symptomatic severe TR that is refractory to medical therapy may be a viable option to improve symptoms in those patients that are unsuitable for surgical intervention.
严重三尖瓣反流(TR)是一种复杂病症,药物治疗可能存在困难,而且由于该干预措施相关的高发病率和死亡率,通常禁止进行手术干预。对于最大程度药物治疗失败且出现与严重TR相关的进行性症状的患者,异位腔静脉瓣膜植入术(CAVI)为缓解这些患者的症状提供了可能。
我们报告两例严重TR且伴有心力衰竭症状的患者,这些症状对药物治疗无效。由于这些患者存在广泛的合并症,手术干预被认为不合适,因此决定进行异位CAVI以尝试控制他们的症状。两名患者均成功接受了该手术,并在美国加利福尼亚州尔湾市的爱德华生命科学公司生产的爱德华SAPIEN 3瓣膜植入下腔静脉/右心房交界处。通过有创和无创方法测量,两名患者术后的血流动力学均有改善。两名患者均成功出院,症状得到改善。
对于药物治疗无效的有症状的严重TR,选择性使用异位CAVI可能是改善那些不适合手术干预患者症状的可行选择。