Qi Ming-Zhu, Su Xiao-Hui, Lin Na, Kong Xiang-Ying
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2021 Jan;46(1):1-5. doi: 10.19540/j.cnki.cjcmm.20200908.601.
Ischemic stroke is the leading cause of death and disability in adults in China. Recent studies have shown that neutrophil extracellular traps play a crucial role in occurrence and development of ischemic stroke. This paper reviewed the literatures on NETs since the discovery of NETs more than a decade ago, and summarized the composition of NETs, the effects of NETs on stroke, the intervention targets of NETs, and the effects of traditional Chinese medicine on NETs. NETs are an important cause of brain injury after stroke. Platelets, peptidylarginine deiminase 4, reactive oxygen species and histones are the targets to regulate NET formation in stroke. There are few researches on traditional Chinese medicine targeting NETs for stroke. Studies on the intervention of traditional Chinese medicine mainly target on neutrophils, which are the main components of NETs, and platelets, which induce the formation of NETs. The paper provided a comprehensive overview of current studies of NETs in ischemic stroke, so as to provide new ideas for the treatment and drug development of ischemic stroke.
缺血性中风是中国成年人死亡和残疾的主要原因。最近的研究表明，中性粒细胞胞外陷阱在缺血性中风的发生和发展中起关键作用。本文回顾了自十多年前发现中性粒细胞胞外陷阱以来的相关文献，总结了中性粒细胞胞外陷阱的组成、其对中风的影响、中性粒细胞胞外陷阱的干预靶点以及中药对中性粒细胞胞外陷阱的影响。中性粒细胞胞外陷阱是中风后脑损伤的重要原因。血小板、肽基精氨酸脱亚氨酶4、活性氧和组蛋白是调节中风中中性粒细胞胞外陷阱形成的靶点。针对中风中中性粒细胞胞外陷阱的中药研究较少。中药干预研究主要针对中性粒细胞（中性粒细胞胞外陷阱的主要成分）和诱导中性粒细胞胞外陷阱形成的血小板。本文全面概述了当前缺血性中风中中性粒细胞胞外陷阱的研究，为缺血性中风的治疗和药物开发提供新思路。
