Department of Nephrology, Mayo Hospital, King Edward Medical University, Lahore, Pakistan.
J Coll Physicians Surg Pak. 2021 Feb;31(2):235-237. doi: 10.29271/jcpsp.2021.02.235.
Rhabdomyolysis constitutes an uncommon cause of acute kidney injury (AKI). A large variety of causes with different pathogenic mechanisms may involve skeletal muscles resulting in rhabdomyolysis with or without acute kidney injury. Crush syndrome and unaccustomed physical exertion are the most common causes of rhabdomyolysis. This study reports local cases of AKI secondary to rhabdomyolysis that presented to a tertiary care centre over a period of four years. Most of them were males and belonged to younger age group. Muscle enzyme creatine phosphokinase level was raised in all patients, while myoglobinuria was detected only in one patient. Most of the patients (10/16) were managed conservatively with fluid replacement; and some of them (6/16) needed dialysis. AKI was resolved in all the patients after a variable period of time. Key Words: Rhabdomyolysis, Acute kidney injury, Myoglobinuria, Creatine phosphokinase, Trauma.
横纹肌溶解症是急性肾损伤（AKI）的一个不常见病因。各种不同发病机制的病因均可累及骨骼肌，导致横纹肌溶解症伴或不伴急性肾损伤。挤压综合征和不常运动是横纹肌溶解症最常见的病因。本研究报告了在四年期间，一家三级医疗中心收治的局部横纹肌溶解症导致的 AKI 病例。这些患者大多为男性，且年龄较小。所有患者的肌肉酶肌酸磷酸激酶水平升高，而仅一位患者检测到肌红蛋白尿。大多数患者（10/16）采用补液治疗的保守方式进行治疗；其中一些患者（6/16）需要透析。所有患者在不同时间后 AKI 均得到缓解。
横纹肌溶解症、急性肾损伤、肌红蛋白尿、肌酸磷酸激酶、创伤。
