School of Pharmacy, The Catholic University of Korea, Bucheon, Korea.
School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.
Expert Rev Pharmacoecon Outcomes Res. 2021 Jun;21(3):395-402. doi: 10.1080/14737167.2021.1897576. Epub 2021 Mar 15.
: Patients with renal cancer are at increased risk of comorbid congestive heart failure (CHF) due to several shared risk factors and the cardiotoxicity of some medications used for renal cancer treatment. We aimed to examine the relationship between CHF and hospital outcomes among renal cancer patients in the U.S.: In this cross-sectional study, we identified hospitalizations of renal cancer patients using the 2015-2017 National Inpatient Sample. We assessed the relationship between CHF and hospital outcomes in this patient population, including in-hospital mortality, length-of-stay (LoS), and hospital costs.: Among the 20,321 hospitalizations of renal cancer patients identified, 6.1% involved patients with comorbid CHF (n = 1,231). The odds of in-hospital mortality did not differ based on CHF presence (odds ratio = 1.21; p = 0.354). Hospitalizations of renal cancer patients with CHF were associated with a greater LoS (incidence rate ratio = 1.44; p < 0.001) and higher hospital costs (cost ratio = 1.27; p < 0.001) than those without CHF.: CHF in renal cancer patients is associated with increased LoS and higher hospital costs. These findings suggest that optimal management of comorbid CHF may improve hospital outcomes in patients with renal cancer and provides evidence to support the emerging field of cardio-oncology.
患者患有肾癌由于存在一些共同的风险因素和某些用于治疗肾癌的药物的心脏毒性,患有充血性心力衰竭(CHF)的风险增加。我们旨在研究美国肾癌患者中 CHF 与医院结局之间的关系:在这项横断面研究中,我们使用 2015-2017 年全国住院患者样本确定了肾癌患者的住院情况。我们评估了该患者人群中 CHF 与医院结局之间的关系,包括院内死亡率、住院时间(LoS)和医院费用。在确定的 20,321 例肾癌患者住院中,有 6.1%的患者合并 CHF(n=1,231)。根据 CHF 的存在,院内死亡率的可能性没有差异(优势比=1.21;p=0.354)。患有 CHF 的肾癌患者的住院时间更长(发病率比=1.44;p<0.001),并且医院费用更高(成本比=1.27;p<0.001)。与没有 CHF 的患者相比。患有肾癌的患者中的 CHF 与较长的 LoS 和更高的医院费用相关。这些发现表明,合并 CHF 的最佳管理可能会改善肾癌患者的医院结局,并为新兴的心脏肿瘤学领域提供证据支持。