Oasis fertility, Hyderabad, India.
Gynecol Endocrinol. 2021 Oct;37(10):891-894. doi: 10.1080/09513590.2021.1892631. Epub 2021 Mar 1.
To evaluate the impact of serum estradiol (E2) levels on cycle outcomes in hormone replacement frozen embryo transfer (HR- FET) cycles.
We retrospectively analyzed 509 HR-FET cycles performed from September 2018 to September 2019. Patients were divided into 6 groups based on their E2 values measured a day before progesterone initiation . Group 1: <100 pg/mL, group 2: 100-200 pg/mL, group 3: 200 - 300 pg/mL, group 4: 300-400 pg/mL, group 5: 400-500 pg/mL, group 6: >500 pg/mL. Implantation rate (IR), clinical pregnancy rate (CPR), miscarriage rate (MR), multiple pregnancy rate (MPR) and ectopic pregnancy rates were compared between all groups.
IR and CPR were similar between a wide range of E2 values, but when E2 values were more than 500 pg/mL there was a non significant fall in the IR (47.3% vs 48.3% vs 48.6% vs 47.8% vs 48.7% vs 39.6% = .77) and CPR (63.6% vs 65.1% vs 65.6% vs 65.3% vs 65.6% vs 53.1% = .692). MR was significantly high when E2 was less than 100 pg/mL (28.5%) and when E2 was more than 500 pg/mL (41.1%) ( = .02). MPR and ectopic pregnancy rates were similar between all the groups.
Outcomes of FET cycles were similar between a wide range of E2 values (100-500 pg/mL). When E2 levels were less than 100 pg/mL or more than 500 pg/mL there was significant increase in the MR but the numbers in these groups are less and further studies are required to confirm these facts.
评估血清雌二醇（E2）水平对激素替代冷冻胚胎移植（HR-FET）周期结局的影响。
我们回顾性分析了 2018 年 9 月至 2019 年 9 月期间进行的 509 例 HR-FET 周期。根据孕激素起始前 1 天测量的 E2 值，患者被分为 6 组。组 1：<100pg/mL；组 2：100-200pg/mL；组 3：200-300pg/mL；组 4：300-400pg/mL；组 5：400-500pg/mL；组 6：>500pg/mL。比较各组间的着床率（IR）、临床妊娠率（CPR）、流产率（MR）、多胎妊娠率（MPR）和异位妊娠率。
在广泛的 E2 值范围内，IR 和 CPR 相似，但当 E2 值超过 500pg/mL 时，IR （47.3% vs 48.3% vs 48.6% vs 47.8% vs 48.7% vs 39.6%）和 CPR（63.6% vs 65.1% vs 65.6% vs 65.3% vs 65.6% vs 53.1%）略有下降（ = .77）。当 E2 小于 100pg/mL 时（28.5%）和 E2 大于 500pg/mL 时（41.1%）MR 显著升高（ = .02）。MPR 和异位妊娠率在所有组间相似。
在广泛的 E2 值范围内（100-500pg/mL），FET 周期的结局相似。当 E2 水平小于 100pg/mL 或大于 500pg/mL 时，MR 显著增加，但这些组的数量较少，需要进一步的研究来证实这些事实。
