Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran | Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Anticancer Agents Med Chem. 2022;22(1):83-100. doi: 10.2174/1871520621666210301085318.
Lung cancer is a malignant disease with high morbidity, mortality, and poor prognosis since conventional therapeutic approaches are not sufficient. Recently, with the discovery of exosomes, researchers have implemented new approaches in the diagnosis and treatment of various malignancies such as lung cancer. Investigation of lung cancer cell-derived exosomes and analysis of their profile by advanced techniques will assist researchers to take advantage of the specific properties of these multivesicular bodies. Also, scientists have presented various encouraging methods in the treatment of lung cancer with loading drugs, proteins, microRNAs, and siRNAs inside specific antigen-targeted exosomes. This review discusses the role of exosomes as novel prognostic biomarkers (containing lipids, surface and internal proteins, miRNAs, and lncRNAs) and therapeutic agents (e.g. vaccine and targeted drug delivery systems) in lung cancer.
肺癌是一种恶性疾病，发病率、死亡率和预后均较差，因为传统的治疗方法并不足够。最近，随着外泌体的发现，研究人员在肺癌等各种恶性肿瘤的诊断和治疗中采用了新方法。研究肺癌细胞来源的外泌体，并通过先进技术分析其特征，将有助于研究人员利用这些多泡体的特定性质。此外，科学家们已经提出了各种有前途的方法，通过将药物、蛋白质、microRNAs 和 siRNAs 装载到特定抗原靶向的外泌体中，来治疗肺癌。本文综述了外泌体作为新型预后生物标志物（含有脂质、表面和内部蛋白、miRNAs 和 lncRNAs）和治疗剂（如疫苗和靶向药物递送系统）在肺癌中的作用。
