Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Infect Disord Drug Targets. 2022;22(2):e170322191922. doi: 10.2174/1871526521666210301142223.
Coronavirus disease 2019 (COVID-19) is a serious viral disease caused by SARS-CoV-2, associated with high morbidity and mortality, and represents a significant public health crisis worldwide. Despite recent efforts for developing novel antiviral agents, no specific drugs are approved for the management and treatment of COVID-19. The immune responses to viral infection followed by cytokine storm and acute respiratory distress syndrome are serious issues that may cause death in patients with severe COVID-19. Therefore, developing a novel therapeutic strategy for the management of COVID-19 is urgently needed to control the virus spread and to improve the patient survival rate and clinical outcomes. In this mini-review, we summarize the symptoms, pathogenesis, and therapeutic approaches currently being used to manage the spread of SARS-CoV-2.
新型冠状病毒病（COVID-19）是由 SARS-CoV-2 引起的一种严重病毒性疾病，具有较高的发病率和死亡率，是全球范围内严重的公共卫生危机。尽管最近在开发新型抗病毒药物方面做出了努力，但目前尚无批准用于 COVID-19 管理和治疗的特定药物。病毒感染后引起的免疫反应、细胞因子风暴和急性呼吸窘迫综合征是严重的问题，可能导致重症 COVID-19 患者死亡。因此，迫切需要开发一种新的治疗策略来管理 COVID-19，以控制病毒传播并提高患者的生存率和临床结果。在这篇迷你综述中，我们总结了目前用于管理 SARS-CoV-2 传播的症状、发病机制和治疗方法。
