Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Rachatawee, Bangkok 10400, Thailand.
Infect Disord Drug Targets. 2022;22(1):e110122191924. doi: 10.2174/1871526521666210301143441.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most infectious diseases which has been caused by coronavirus in 2019 (COVID-19). It has widely spread worldwide and infected more than 28 million people in 215 countries, and more than 920,000 have now died from COVID-19. To date, no effective antiviral drugs or specific vaccines have been discovered yet. Considering this situation, the potential therapeutic antiviral drug targets for the COVID-19 are being repurposed to speed up the discovery of effective treatment. The most potential drug targets that are continuously being recommended include Favipiravir, Chloroquine, Hydroxychloroquine, and Remdesivir. Moreover, the antiviral target proteins and anti-host target proteins are being reported continuously. This review has summarized the current research studies on potential therapeutic drug targets that are being tested against the SARS-CoV-2. It will provide information related to potential repurposing drugs for overcoming COVID-19.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是由冠状病毒引起的 2019 年（COVID-19）最具传染性的疾病之一。它已在全球范围内广泛传播，在 215 个国家感染了超过 2800 万人，目前已有超过 92 万人死于 COVID-19。迄今为止，尚未发现有效的抗病毒药物或特定疫苗。鉴于这种情况，正在重新利用有治疗潜力的抗病毒药物靶点，以加快有效治疗方法的发现。目前持续推荐的最有潜力的药物靶点包括法匹拉韦、氯喹、羟氯喹和瑞德西韦。此外，抗病毒目标蛋白和抗宿主目标蛋白也在不断被报道。这篇综述总结了目前针对 SARS-CoV-2 正在测试的潜在治疗药物靶点的研究。它将提供有关克服 COVID-19 的潜在再利用药物的信息。
