Upasham Sayali, Churcher Nathan Kodjo Mintah, Rice Paul, Prasad Shalini
Department of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
ACS Sens. 2021 Mar 26;6(3):659-672. doi: 10.1021/acssensors.0c02622. Epub 2021 Mar 1.
Circadian dysfunction or dysregulation is associated with many chronic morbidities. Current state-of-art technologies do not provide an accurate estimation of the extent of disease affliction. Recent advances call for using wearables for improving management and diagnosis of circadian related disorders. Sweat contains an abundance of relevant biomarkers like cortisol, DHEA, and so forth, which could be leveraged toward tracking the user's chronobiology. In this article, we provide a review of the key developments in the field of wearable sensors for circadian technologies. We highlight the value of using sweat along with portable electronics toward developing state-of-the-art platforms for efficient diagnosis and management of chronic conditions. Finally, we discuss challenges and opportunities for using wearable sweat sensors for circadian diagnosis and disease management.
昼夜节律功能障碍或失调与许多慢性疾病相关。当前的先进技术无法准确估计疾病的患病程度。最近的进展要求使用可穿戴设备来改善昼夜节律相关疾病的管理和诊断。汗液中含有丰富的相关生物标志物，如皮质醇、脱氢表雄酮等，可用于追踪用户的生物钟学。在本文中，我们综述了用于昼夜节律技术的可穿戴传感器领域的关键进展。我们强调了将汗液与便携式电子设备结合使用，以开发用于慢性疾病高效诊断和管理的先进平台的价值。最后，我们讨论了使用可穿戴汗液传感器进行昼夜节律诊断和疾病管理的挑战与机遇。
