Department of Radiology, Tianjin Medical University General Hospital, Anshan Road No 154, Heping District, Tianjin 300052, China; Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China; School of Medical Imaging, Tianjin Medical University, Tianjin 300070, China.
Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China; School of Medical Imaging, Tianjin Medical University, Tianjin 300070, China.
Neuroimage. 2021 May 15;232:117868. doi: 10.1016/j.neuroimage.2021.117868. Epub 2021 Feb 27.
Studies have indicated that the dorsal attention network (DAN) and the ventral attention network (VAN) functionally interact via several fronto-parietal connector hubs. However, the anatomical connectivity profiles of these connector hubs, and the coupling between the anatomical and functional connectivities of them, are still unknown. In the present study, we found that functional connector hubs anatomically bridged the DAN and VAN based on multimodal magnetic resonance imaging data from the Human Connectome Project (HCP) Consortium and an independent Chinese cohort. The three hubs had unique anatomical connectivity patterns with the attention sub-networks. For each connector hub, the pattern of anatomical connectivity resembled the functional one. Finally, the strength of the anatomical connectivity of these connector hubs was positively associated with the functional connectivity at the group- and individual-levels. Our findings help to better understand the anatomical mechanisms underlying the functional interactions between the DAN and the VAN.
研究表明，背侧注意网络（DAN）和腹侧注意网络（VAN）通过几个额顶连接器枢纽在功能上相互作用。然而，这些连接器枢纽的解剖连通性特征，以及它们的解剖和功能连通性之间的耦合，仍然未知。在本研究中，我们发现功能连接器枢纽基于多模态磁共振成像数据从人类连接组计划（HCP）联盟和一个独立的中国队列在解剖上连接了 DAN 和 VAN。这三个枢纽与注意力子网具有独特的解剖连接模式。对于每个连接器枢纽，解剖连接模式与功能连接模式相似。最后，这些连接器枢纽的解剖连接强度与组内和个体水平的功能连接强度呈正相关。我们的研究结果有助于更好地理解 DAN 和 VAN 之间功能相互作用的解剖机制。
