Laboratory of Health and Sports Sciences, Meiji Gakuin University, Kanagawa, Japan.
Faculty of Health and Medical Science, Teikyo Heisei University, Chiba, Japan.
J Int Soc Sports Nutr. 2021 Mar 1;18(1):18. doi: 10.1186/s12970-021-00411-x.
We previously showed 8-week of fish oil supplementation attenuated muscle damage. However, the effect of a shorter period of fish oil supplementation is unclear. The present study investigated the effect of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for 4 weeks on muscular damage caused by eccentric contractions (ECCs) of the elbow flexors.
Twenty-two untrained men were recruited in this double-blind, placebo-controlled, parallel design study and the subjects were randomly assigned to the EPA and DHA group (EPA and DHA, n = 11) and placebo group (PL, n = 11). They consumed either EPA 600 mg and DHA 260 mg per day or placebo supplement for 4 weeks prior to exercise. Subjects performed 60 ECCs at 100 % maximal voluntary contraction (MVC) using a dumbbell. Changes in MVC torque, range of motion (ROM), upper arm circumference, muscle soreness, echo intensity, muscle thickness, serum creatine kinase (CK), and interleukin-6 (IL-6) were assessed before exercise; immediately after exercise; and 1, 2, 3, and 5 days after exercise.
ROM was significantly higher in the EPA and DHA group than in the PL group immediately after performing ECCs (p < 0.05). No differences between groups were observed in terms of MVC torque, upper arm circumference, muscle soreness, echo intensity, and thickness. A significant difference was observed in serum CK 3 days after ECCs (p < 0.05).
We concluded that shorter period EPA and DHA supplementation benefits joint flexibility and protection of muscle fiber following ECCs.
我们之前的研究表明，8 周的鱼油补充可以减轻肌肉损伤。然而，较短时间的鱼油补充的效果尚不清楚。本研究旨在探讨鱼油、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）补充 4 周对肱二头肌离心收缩（ECCs）引起的肌肉损伤的影响。
本双盲、安慰剂对照、平行设计研究共招募了 22 名未经训练的男性，将受试者随机分为 EPA 和 DHA 组（EPA 和 DHA，n=11）和安慰剂组（PL，n=11）。他们在运动前 4 周内每天分别服用 EPA 600mg 和 DHA 260mg 或安慰剂补充剂。受试者使用哑铃进行 100%最大自主收缩（MVC）的 60 次 ECC。在运动前、运动后即刻、运动后 1、2、3 和 5 天评估 MVC 扭矩、运动范围（ROM）、上臂周长、肌肉酸痛、回波强度、肌肉厚度、血清肌酸激酶（CK）和白细胞介素-6（IL-6）的变化。
ECC 后，EPA 和 DHA 组的 ROM 明显高于 PL 组（p<0.05）。两组间 MVC 扭矩、上臂周长、肌肉酸痛、回波强度和厚度无差异。ECC 后 3 天，血清 CK 差异有统计学意义（p<0.05）。
我们得出结论，较短时间的 EPA 和 DHA 补充可以改善关节灵活性和 ECC 后肌肉纤维的保护。
