Department of Chemistry, Duke University, Durham, NC, USA.
Department of Anesthesiology, Center for Translational Pain Medicine, Duke University, Durham, NC, USA.
Nat Commun. 2021 Mar 1;12(1):1367. doi: 10.1038/s41467-021-21438-3.
Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to facilitate a diverse array of release profiles would serve to advance patient comfort, quality of care and compliance following surgical procedures. Herein, we review current polymeric systems that could be utilized in new, controlled post-operative pain management devices and highlight where opportunities for improvement exist.
有效的疼痛管理控制有可能显著减少手术后对处方类阿片类药物的需求。虽然市面上有用于疼痛管理的控释产品,但如果有一种设备能够安全可靠地提供长效镇痛作用,并且具有足够的灵活性来实现各种不同的释放曲线,那么这将有助于提高患者手术后的舒适度、护理质量和治疗依从性。在此,我们综述了可用于新型术后疼痛管理设备的现有聚合物系统,并强调了存在改进机会的领域。