某些头孢菌素、红霉素和苯唑西林的口服剂型对多杀巴斯德菌缺乏体外有效性。
Lack of in vitro efficacy of oral forms of certain cephalosporins, erythromycin, and oxacillin against Pasteurella multocida.
作者信息
Goldstein E J, Citron D M, Richwald G A
机构信息
R.M. Alden Research Laboratory, Santa Monica Hospital Medical Center, California 90404.
出版信息
Antimicrob Agents Chemother. 1988 Feb;32(2):213-5. doi: 10.1128/AAC.32.2.213.
Abstract
The in vitro susceptibility of human isolates of Pasteurella multocida to oral antimicrobial agents from our current study and from a review of the literature suggests that dicloxacillin (oxacillin), erythromycin, clindamycin, cephalexin, cefaclor, and cefadroxil should not be used for empiric therapy of animal bite wounds. Agents that were consistently active against P. multocida were penicillin, ampicillin, amoxicillin-clavulanic acid, tetracycline, minocycline, chloramphenicol, trimethoprim-sulfamethoxazole, and cefuroxime. Possible reasons for the confusion regarding the activity of oral cephalosporins are addressed.
摘要
从我们当前的研究以及文献综述来看，多杀巴斯德菌的人体分离株对口服抗菌药物的体外敏感性表明，双氯西林（苯唑西林）、红霉素、克林霉素、头孢氨苄、头孢克洛和头孢羟氨苄不应被用于动物咬伤伤口的经验性治疗。对多杀巴斯德菌始终有效的药物有青霉素、氨苄西林、阿莫西林-克拉维酸、四环素、米诺环素、氯霉素、甲氧苄啶-磺胺甲恶唑和头孢呋辛。文中探讨了口服头孢菌素活性方面存在混淆的可能原因。
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