Minato Keitaro, Hirano Toru, Kawashima Hiroyuki, Yamagishi Tetsuro, Watanabe Kei, Ohashi Masayuki, Ogose Akira, Endo Naoto
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Department of Orthopedic Surgery, Uonuma Kikan Hospital.
Acta Med Okayama. 2021 Feb;75(1):95-101. doi: 10.18926/AMO/61442.
A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT.
一名21岁男性因治疗Enneking III期脊柱巨细胞瘤（GCT）前来我院就诊。下腰椎肿瘤和严重的椎管狭窄与手术高发病率相关。通过经皮椎弓根螺钉固定联合地诺单抗暂时确保了稳定性，地诺单抗使肿瘤缩小。在开始使用地诺单抗6个月后进行了全椎体整块切除术，并对患者进行了3年的随访。无局部复发，实现了骨融合。微创手术和地诺单抗使下腰椎室外型GCT的治疗更安全、更容易。
