Xu Xiaolei, Lu Yanqiu, Harypursat Vijay, Sun Feng, Zhao Ting, Zeng Yanming, He Xiaoqing, Chen Yaokai
Division of Infectious Diseases, Chongqing Public Health Medical Center.
Acta Med Okayama. 2021 Feb;75(1):109-113. doi: 10.18926/AMO/61443.
The optimal timing of antiretroviral therapy (ART) initiation in human immunodeficiency virus (HIV)-infected patients with cryptococcal meningitis (HIV/CM) is controversial. We designed a clinical trial to inves-tigate the optimal timing for ART initiation in HIV/CM patients. This will be a multicenter, prospective, and randomized clinical trial. Each enrolled patient will be randomized into either the early ART arm or the deferred ART arm. We will compare the mortality and incident rates of immune reconstitution inflammatory syndrome between the two arms. We hope to elucidate the optimal timing for ART initiation in HIV/CM patients.
在感染人类免疫缺陷病毒（HIV）的隐球菌性脑膜炎（HIV/CM）患者中，抗逆转录病毒疗法（ART）开始的最佳时机存在争议。我们设计了一项临床试验，以研究HIV/CM患者开始ART的最佳时机。这将是一项多中心、前瞻性随机临床试验。每个入组患者将被随机分为早期ART组或延迟ART组。我们将比较两组之间免疫重建炎症综合征的死亡率和发生率。我们希望阐明HIV/CM患者开始ART的最佳时机。
