Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Transfusion. 2021 May;61(5):1479-1488. doi: 10.1111/trf.16336. Epub 2021 Mar 2.
Blood donors report better health-related quality of life (HRQL) than non-donors. Likewise, donors reporting good health are less likely to stop donating and have a higher donation frequency. This is evidence of the healthy donor effect (HDE). This study is the first to investigate the impact of HRQL and depressive symptoms on subsequent donor career.
Prospective cohort study includes 102,065 participants from the Danish Blood Donor Study applying the 12-item short-form health survey (SF-12) measuring a mental (MCS) and a physical component score (PCS) and the Major Depression Inventory (MDI). Poisson and Cox regression models were used to assess the effect of SF-12 and MDI scores on donation frequency and donor cessation. Higher MCS/PCS scores indicate good HRQL, while higher MDI score indicates higher experience of depressive symptoms.
For both sexes, MCS was positively correlated with donation frequency for up to 5 years, and similarly for PCS among women. A negative correlation between MDI score and donation frequency in the year following assessment was observed only among men. No correlation was observed among women. An increase in both MCS and PCS was associated with a lower risk of donation cessation in both sexes, while an increase in MDI score was only associated with an increased risk of donation cessation in men.
MCS, PCS, and MDI score affect donor career. Thus, adjusting for donation frequency may reduce HDE-bias in donor health research. However, because of the small effect sizes, other ways of quantifying HDE may be beneficial.
献血者报告的健康相关生活质量（HRQL）优于非献血者。同样，报告健康状况良好的献血者不太可能停止献血，并且献血频率更高。这就是健康献血者效应（HDE）的证据。这项研究首次调查了 HRQL 和抑郁症状对随后的献血者生涯的影响。
前瞻性队列研究包括来自丹麦献血者研究的 102065 名参与者，他们应用 12 项简短健康调查（SF-12）来衡量心理（MCS）和身体成分评分（PCS）和主要抑郁量表（MDI）。使用泊松和 Cox 回归模型评估 SF-12 和 MDI 评分对献血频率和献血者停止献血的影响。较高的 MCS/PCS 评分表示良好的 HRQL，而较高的 MDI 评分表示较高的抑郁症状体验。
对于男性和女性，MCS 与最多 5 年内的献血频率呈正相关，而 PCS 也与女性的献血频率呈正相关。仅在男性中观察到评估后一年 MDI 评分与献血频率之间的负相关。在女性中未观察到相关性。MCS 和 PCS 的增加均与男性和女性的献血者停止献血的风险降低相关，而 MDI 评分的增加仅与男性的献血者停止献血的风险增加相关。
MCS、PCS 和 MDI 评分会影响献血者的生涯。因此，调整献血频率可能会降低献血者健康研究中的 HDE 偏差。然而，由于效应量较小，其他量化 HDE 的方法可能会有所帮助。
