Dispagna Mauro Antonio, Daneshvar Michael, Bratslavsky Gennady
College of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States.
Department of Urology, SUNY Upstate Medical University, Syracuse, NY, United States.
Int Braz J Urol. 2021 Sep-Oct;47(5):935-942. doi: 10.1590/S1677-5538.IBJU.2020.0778.
To review the current literature regarding variant (non-clear) histology of renal cell carcinoma (RCC) and the clinical management of these renal tumors.
A PubMed database search was performed in May 2020 focusing on variant RCC, its diagnosis and associated syndromes, tumor characteristics, and options for management.
A broad range of pathological, clinical and diagnostic characteristics amongst non-ccRCC variants were found to have an impact on the overall management of these tumors. The imaging modalities, frequency of surveillance, and timing for intervention were found to be dependent on the type of genetic alterations, type of histology, and tumor growth rates. The timing and type of surgery as well as the systemic therapy are tailored to the specific tumor type and patient.
The findings of this review suggest that clinical management should be considered and adjusted for patients with non-ccRCC histological variants based on tumor subtype and genetic alterations.
回顾关于肾细胞癌（RCC）变异（非透明）组织学以及这些肾肿瘤临床管理的当前文献。
2020年5月对PubMed数据库进行搜索，重点关注变异型RCC、其诊断及相关综合征、肿瘤特征以及管理选择。
发现非透明细胞肾细胞癌（non-ccRCC）变异型之间广泛的病理、临床和诊断特征对这些肿瘤的整体管理有影响。影像学检查方式、监测频率和干预时机取决于基因改变类型、组织学类型和肿瘤生长速度。手术时机和类型以及全身治疗均根据特定肿瘤类型和患者进行调整。
本综述结果表明，对于具有non-ccRCC组织学变异型的患者，应根据肿瘤亚型和基因改变来考虑并调整临床管理。
