Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poznań, Poland.
Expert Opin Pharmacother. 2021 Jun;22(9):1167-1177. doi: 10.1080/14656566.2021.1880567. Epub 2021 Mar 2.
: Depressive disorders are common in older patients, and their prevalence may reach up to 17.1%. Though for older adults, the initial recommended treatment is either life-review treatment or group cognitive-behavioral therapy, a combination of pharmacotherapy with interpersonal psychotherapy is also an option. There are many classes of antidepressants, and some meta-analyses suggest that the efficacy of different antidepressant groups is similar. Therefore, depression treatment in an elderly patient should consider preference, safety, and tolerability. Most reports suggest that SSRIs, such as citalopram, escitalopram, or sertraline, should be proposed as first-time medications.: This article discusses the pharmacokinetic and pharmacodynamic properties of vortioxetine, emphasizing the observed differences, benefits, and risks for older patients. Vortioxetine - a multimodal antidepressant drug - was shown to be effective against major depressive disorders in both double-blinded, placebo-controlled trials and open-label studies.: Compared with commonly used antidepressants, vortioxetine appears to have unique properties that may be beneficial for elderly patients. Not only does it enhance cognitive function, but it also has a favorable safety profile.
: 抑郁障碍在老年患者中很常见，其患病率可能高达 17.1%。尽管对于老年人，初始推荐的治疗方法是生活回顾治疗或团体认知行为疗法，但药物治疗联合人际心理治疗也是一种选择。抗抑郁药有很多种类，一些荟萃分析表明，不同抗抑郁药群组的疗效相似。因此，老年患者的抑郁治疗应考虑偏好、安全性和耐受性。大多数报告表明，SSRI 类药物，如西酞普兰、艾司西酞普兰或舍曲林，应作为首选药物。: 本文讨论了沃替西汀的药代动力学和药效学特性，强调了观察到的对老年患者的差异、益处和风险。沃替西汀——一种多模式抗抑郁药——在双盲、安慰剂对照试验和开放标签研究中均显示对重度抑郁症有效。: 与常用的抗抑郁药相比，沃替西汀似乎具有独特的特性，对老年患者可能有益。它不仅能增强认知功能，而且具有良好的安全性。
