Kritchevsky D, Tepper S A, Weber M M, Klurfeld D M
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Artery. 1988;15(3):163-9.
Atherosclerosis was established in rabbits by feeding 1% cholesterol and 4% corn oil for two months. The rabbits were placed into five groups of equal average cholesterol level (2876 mg/dl) one of which was autopsied. The four remaining groups were placed on commercial ration (CR), CR plus 4% corn oil, or semipurified diets containing 14% coconut oil and 25% soy protein or casein. After two months, serum cholesterol levels in CR, CR plus corn oil, soy and casein groups had fallen by 91, 80, 81, and 64%, respectively. Aortic sudanophilia (%) in these four groups had increased by 106, 213, 238, and 25%, respectively. The findings confirm earlier observations that rabbit atherosclerosis does not regress when the atherogenic stimulus is removed.
通过给兔子喂食1%胆固醇和4%玉米油两个月来诱发动脉粥样硬化。将兔子分为五组，每组平均胆固醇水平相等（2876毫克/分升），其中一组进行尸检。其余四组分别给予商业日粮（CR）、CR加4%玉米油，或含有14%椰子油和25%大豆蛋白或酪蛋白的半纯化日粮。两个月后，CR组、CR加玉米油组、大豆蛋白组和酪蛋白组的血清胆固醇水平分别下降了91%、80%、81%和64%。这四组的主动脉苏丹红染色阳性率（%）分别增加了106%、213%、238%和25%。这些发现证实了早期的观察结果，即去除致动脉粥样硬化刺激后，兔子的动脉粥样硬化不会消退。
