From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Department of Pulmonology, Clinic Penzing, Vienna Health Care Group, Vienna, Austria.
J Intern Med. 2021 Aug;290(2):437-443. doi: 10.1111/joim.13275. Epub 2021 Mar 21.
Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.
This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.
Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.
COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.
2019 年冠状病毒病（COVID-19）会影响血管内皮。目前尚不清楚 COVID-19 是否会进一步影响动脉僵硬度。
本病例对照研究比较了急性发病的 COVID-19 患者与无 COVID-19 患者的肱踝脉搏波速度（baPWV）和颈股脉搏波速度（cfPWV）。
22 例 COVID-19 患者（女性占 50%，77[67-84]岁）与 22 名年龄和性别匹配的对照者进行了比较。在 COVID-19 患者中，baPWV（19.9[18.4-21.0]比 16.0[14.2-20.4]，P=0.02）和 cfPWV（14.3[13.4-16.0]比 11.0[9.5-14.6]，P=0.01）均高于对照组。多元回归分析显示，COVID-19 与 cfPWV 升高独立相关（β=3.164，P=0.004）和 baPWV 升高独立相关（β=3.532，P=0.003）。在幸存者中，PWV 与住院时间相关。
COVID-19 似乎与 PWV 升高有关，反映了动脉僵硬度的增加。较高的 PWV 可能与住院时间延长和死亡率增加有关。
