Department of Radiology, Mie University, Tsu, Japan.
Department of Thoracic Surgery, Mie University, Tsu, Japan.
Thorac Cancer. 2021 Apr;12(8):1252-1255. doi: 10.1111/1759-7714.13911. Epub 2021 Mar 2.
The management of synchronous multiple primary lung cancer is a challenge. In this report, we describe our experience in a patient with three synchronous multiple cancers. The first lesion was completely surgically removed, the second lesion received postoperative irradiation, and the third lesion was treated with radiotherapy alone. Radiation therapies were performed using a combination of external irradiation and endobronchial brachytherapy. Endobronchial brachytherapy is an effective radiation therapy for endobronchial tumors owing to its advantage of high-dose concentration. However, adverse events (AEs) such as hemoptysis or severe bronchitis are a problem. Thus, we have developed an applicator to keep the radioactive source in the center of the bronchial lumen. A total of 28 months after treatment, the patient had not experienced any relapses or AEs. Endobronchial brachytherapy using an applicator can be an alternative treatment for cases in which surgery is expected to lead to pulmonary dysfunction.
同步多原发性肺癌的治疗具有挑战性。在本报告中，我们描述了一名患有三种同步多癌症患者的治疗经验。第一个病变完全手术切除，第二个病变接受术后放疗，第三个病变单独接受放疗。放射治疗采用外照射和支气管内近距离放疗相结合的方法进行。支气管内近距离放疗由于其高剂量浓度的优势，是治疗支气管内肿瘤的有效方法。然而，咯血或严重支气管炎等不良反应（AE）是一个问题。因此，我们开发了一种施源器，将放射性源保持在支气管腔的中心。治疗后 28 个月，患者未出现任何复发或 AE。使用施源器进行支气管内近距离放疗可以作为一种替代治疗方法，适用于手术可能导致肺功能障碍的病例。
