De Wit L E, Dekker D
UMC Utrecht, afd. Psychiatrie, Utrecht (thans: St. Antonius Ziekenhuis, Utrecht/Nieuwegein).
Contact: L.E. De Wit (
Ned Tijdschr Geneeskd. 2021 Feb 25;164:D5172.
Drug of abuse (DOA) screening in urine is often performed in the clinical emergency setting. However, there is considerable evidence that questions the usefulness of this screening in the acute management of patients with suspected intoxications. The used method is an immunoassay, in which cross reactivity with false positive results may occur. A positive result does not always indicate current toxicity, a negative result does not exclude drug use or a current intoxication. Therefore, DOA screening has limited value in the acute clinical management of patients with intoxications.
尿液中的药物滥用(DOA)筛查常在临床急诊环境中进行。然而,有大量证据对这种筛查在疑似中毒患者急性处理中的效用提出质疑。所采用的方法是免疫测定法,可能会出现与假阳性结果的交叉反应。阳性结果并不总是表明当前存在毒性,阴性结果也不能排除药物使用或当前中毒情况。因此,DOA筛查在中毒患者的急性临床处理中的价值有限。