Department of Radiology, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.
Department of Pathology, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.
Neurochirurgie. 2022 Jan;68(1):106-112. doi: 10.1016/j.neuchi.2021.02.006. Epub 2021 Feb 27.
Pituitary carcinomas are rare, with only a few case reports to date. We present a null cell type non-functioning pituitary carcinoma (NFPC) with intracranial metastases and a review of the literature.
A 56-year-old male with a history of an aggressive pituitary adenoma was admitted. Initial MRI highlighted a large intracranial mass with leptomeningeal involvement, simulating meningioma. Based on his previous pathology report of the sellar mass, a diagnosis of null cell type non-functioning pituitary carcinoma has been made.
An aggressive recurrent pituitary tumor with suprasellar and/or cavernous sinus invasion is the main characteristics of the NFPC. Single or multiple enhancing dural-based mass(es) mimicking meningioma is the most common MRI finding. The proof of malignancy is the same histopathological features of the recurrent aggressive pituitary tumor in the metastases. The histology alone is not distinctive in terms of malignancy. Most patients require a combined surgery, radiotherapy and chemotherapy.
垂体癌罕见，迄今为止仅有少数病例报告。我们报告了一例伴有颅内转移的无分泌功能的垂体癌（NFPC），并进行了文献复习。
一名 56 岁男性，既往有侵袭性垂体腺瘤病史，因病情加重入院。最初的 MRI 显示颅内有一个大的肿块，伴有脑膜累及，类似于脑膜瘤。根据他之前鞍区肿块的病理报告，诊断为无分泌功能的垂体癌。
具有鞍上和/或海绵窦侵犯的侵袭性复发性垂体肿瘤是 NFPC 的主要特征。单一或多个增强的硬脑膜基底部肿块（s）类似于脑膜瘤是最常见的 MRI 发现。恶性肿瘤的证据是转移灶中复发性侵袭性垂体肿瘤的相同组织病理学特征。单纯的组织学在恶性程度上没有明显的特征。大多数患者需要综合手术、放疗和化疗。
