用灭活疫苗保护小鼠免受疟疾感染：针对约氏疟原虫和伯氏疟原虫的有效性差异。
Protection of mice against malaria by a killed vaccine: differences in effectiveness against P. yoelii and P. berghei.
作者信息
Playfair J H, De Souza J B, Cottrell B J
出版信息
Immunology. 1977 Oct;33(4):507-15.
Abstract
(C57BI x Balb/c)F1 mice are normally killed by a strain of the malaria P. yoelii, but they can be fully protected by a killed vaccine. The best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0-06% formalin and injected intravenously with the adjuvant B. pertussis, though good protection was also obtained without the adjuvant. The protection was specific and at least partly mediated by a serum factor. A similar regime gives little or no protection against P. berghei. Possible reasons for this difference are considered and the mechanisms by which vaccination works against P. yoelii are discussed.
摘要
（C57BI×Balb/c）F1小鼠通常会被约氏疟原虫的一个菌株致死，但它们可以通过一种灭活疫苗得到完全保护。用皂苷裂解的被寄生细胞，随后用0.06%的福尔马林固定，并与百日咳杆菌佐剂一起静脉注射，可获得最佳效果，不过在没有佐剂的情况下也能获得良好的保护效果。这种保护是特异性的，至少部分是由一种血清因子介导的。类似的方案对伯氏疟原虫几乎没有或没有保护作用。文中考虑了造成这种差异的可能原因，并讨论了疫苗针对约氏疟原虫起作用的机制。
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