Playfair J H, De Souza J B, Cottrell B J
Immunology. 1977 Oct;33(4):507-15.
(C57BI x Balb/c)F1 mice are normally killed by a strain of the malaria P. yoelii, but they can be fully protected by a killed vaccine. The best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0-06% formalin and injected intravenously with the adjuvant B. pertussis, though good protection was also obtained without the adjuvant. The protection was specific and at least partly mediated by a serum factor. A similar regime gives little or no protection against P. berghei. Possible reasons for this difference are considered and the mechanisms by which vaccination works against P. yoelii are discussed.
(C57BI×Balb/c)F1小鼠通常会被约氏疟原虫的一个菌株致死,但它们可以通过一种灭活疫苗得到完全保护。用皂苷裂解的被寄生细胞,随后用0.06%的福尔马林固定,并与百日咳杆菌佐剂一起静脉注射,可获得最佳效果,不过在没有佐剂的情况下也能获得良好的保护效果。这种保护是特异性的,至少部分是由一种血清因子介导的。类似的方案对伯氏疟原虫几乎没有或没有保护作用。文中考虑了造成这种差异的可能原因,并讨论了疫苗针对约氏疟原虫起作用的机制。