结直肠癌中的放射基因组学
Radiogenomics in Colorectal Cancer.
作者信息
Badic Bogdan, Tixier Florent, Cheze Le Rest Catherine, Hatt Mathieu, Visvikis Dimitris
机构信息
National Institute of Health and Medical Research, LaTIM-Laboratory of Medical Information Processing (INSERM LaTIM), UMR 1101, Université Bretagne Occidentale, 29238 Brest, France.
Department of Nuclear Medicine, University Hospital of Poitiers, 86021 Poitiers, France.
出版信息
Cancers (Basel). 2021 Feb 26;13(5):973. doi: 10.3390/cancers13050973.
Abstract
The steady improvement of high-throughput technologies greatly facilitates the implementation of personalized precision medicine. Characterization of tumor heterogeneity through image-derived features-radiomics and genetic profile modifications-genomics, is a rapidly evolving field known as radiogenomics. Various radiogenomics studies have been dedicated to colorectal cancer so far, highlighting the potential of these approaches to enhance clinical decision-making. In this review, a general outline of colorectal radiogenomics literature is provided, discussing the current limitations and suggested further developments.
摘要
高通量技术的稳步改进极大地促进了个性化精准医学的实施。通过图像衍生特征（放射组学）和基因谱修饰（基因组学）来表征肿瘤异质性，是一个快速发展的领域，称为放射基因组学。到目前为止，各种放射基因组学研究都致力于结直肠癌，突出了这些方法在加强临床决策方面的潜力。在这篇综述中，提供了结直肠癌放射基因组学文献的概述，讨论了当前的局限性并提出了进一步的发展建议。
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