Fritz H
Ciba-Geigy Ltd., Basle, Switzerland.
Arzneimittelforschung. 1988 Jan;38(1):50-4.
Pregnant female albino rats were treated orally with lithium carbonate dissolved in distilled water. Treatment at 100 mg/kg day 16 until day 20 of gestation caused marked maternal toxicity including polyuria. For the progeny increased rates of prenatal and postnatal mortality were noted. In part of the progeny sacrificed near term by Caesarean section, the visceral examination of the fetuses revealed an enlargement of the renal pelves in association with rudimentary or missing papillae. The renal anomalies are interpreted as being consistent with a developmental retardation due to specific lithium activity. After birth, i.e. after termination of maternal treatment, slight to moderate structural changes of the kidney were apparently compensated. 60 mg/kg through days 16-20 of pregnancy caused moderate maternal toxicity including polyuria. The offspring showed a postnatal development near the normal range, however, and no renal anomalies were recorded. In the view of the nephrotrophic property of lithium as known for the adult rat, the results indicate that possible transplacental effects on the fetal kidney as a target organ should be also considered.
将碳酸锂溶解于蒸馏水中，对怀孕的雌性白化病大鼠进行口服给药。在妊娠第16天至第20天以100毫克/千克的剂量进行治疗，导致明显的母体毒性，包括多尿。对于后代，观察到产前和产后死亡率增加。在部分通过剖腹产在接近足月时处死的后代中，对胎儿进行的内脏检查显示肾盂扩大，并伴有乳头发育不全或缺失。肾异常被解释为与锂的特定活性导致的发育迟缓一致。出生后，即母体治疗终止后，肾脏的轻度至中度结构变化显然得到了代偿。在妊娠第16天至第20天以60毫克/千克的剂量给药，导致中度母体毒性，包括多尿。然而，后代的产后发育接近正常范围，并且未记录到肾异常。鉴于已知锂对成年大鼠具有肾营养特性，结果表明，也应考虑锂对作为靶器官的胎儿肾脏可能产生的经胎盘影响。
