Abdel-Ghaffar Amany, Elhossary Ghada G, Mahmoud Atef M, Elshazly Amany H M, Hassanin Olfat A, Saleh Anisa, Mansour Sahar M, Metwally Fatma G, Hanafy Laila K, Karam Sawsan H, Darweesh Neveen, Ata Ahmed Mostafa
Department of Biochemistry, Research Institute of Ophthalmology, Giza, Egypt.
Department of Pharmacology, Research Institute of Ophthalmology, Giza, Egypt.
Arch Physiol Biochem. 2023 Dec;129(4):964-974. doi: 10.1080/13813455.2021.1888302. Epub 2021 Mar 2.
There are good evidences suggesting that endoplasmic reticulum (ER) stress can be one of the contributing factors in the development of diabetic retinopathy. The present study was designed to investigate the effect of chemical chaperone 4-phenylbutyric acid (4-PBA) in alleviating the ER stress, and diabetic retinopathy in type 2 diabetic rats. Treatment of diabetic rats with 4-PBA, increased the antioxidant capacity, reduced the levels of lipid peroxidation, organised the state of apoptosis and regulated the ER stress - oxidative activation in retinal tissue. Also there was an improvement in the histological picture of retinal specimens compared to untreated diabetic rats. It was concluded that 4-PBA is a promising therapeutic agent for ER stress diseases such as diabetic retinopathy.
有充分证据表明内质网（ER）应激可能是糖尿病视网膜病变发生发展的促成因素之一。本研究旨在探讨化学伴侣4-苯基丁酸（4-PBA）在减轻2型糖尿病大鼠内质网应激及糖尿病视网膜病变方面的作用。用4-PBA治疗糖尿病大鼠，可提高抗氧化能力，降低脂质过氧化水平，改善凋亡状态并调节视网膜组织中的内质网应激-氧化激活。与未治疗的糖尿病大鼠相比，视网膜标本的组织学图像也有所改善。得出的结论是，4-PBA是治疗诸如糖尿病视网膜病变等内质网应激疾病的一种有前景的治疗药物。
